Is high intensity exercise good for older people ?

Time is precious even for retired older people. People struggle to do longer duration of exercise every week.

Hence high intensity exercise – intense but short duration exercise- has become the favourite for busy individuals . ( See Mayo clinic Website and NHS website for Information about Exercise Intensity)

A Norwegian group compared high intensity exercise with medium intensity exercise in 1567 participants. The study involved a older population with an average age of 72.8 years.

People who did high intensity seem to have a trend towards longer life expectancy in the study.

Although study results are not definitive for all types of exercise, it’s terms of starting to do regular exercise , it’s never too late to start exercising !

References:

(1). Effect of exercise training for five years on all cause mortality in older adults—the Generation 100 study: randomised controlled trial
BMJ 2020; 371
doi: https://doi.org/10.1136/bmj.m3485 (Published 07 October 2020)
Cite this as: BMJ 2020;371:m3485.

(2). BMJ blogs. It’s never too late for older adults to start exercising. October 7, 2020

(3). Physical activity trajectories and mortality: population based cohort study. BMJ 2019; 365 doi: https://doi.org/10.1136/bmj.l2323 (Published 26 June 2019)

(4) Mayo Clinic: Exercise intensity: How to measure it.

(5). NHS website: Physical activity guidelines for older adults.

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of drafting the blog and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

Coronavirus : Why Hand hygiene is also important in addition to Face mask ?

The UK government’s slogan for controlling COVID-19 pandemic is “ ‘Hands. Face. Space

The reason hands are emphasised is because the Virus can stay alive on Human skin for many hours. So touching others by hugging or hand shaking can spread the virus.

A recent Japanese study found that Coronavirus can stay alive on skin surfaces for about 9 hours. They also found that alcohol gel can inactivate the virus in about 15 seconds !

References:

1. Survival of SARS-CoV-2 and influenza virus on the human skin: Importance of hand hygiene in COVID-19 Ryohei Hirose, Hiroshi Ikegaya, Yuji Naito, Naoto Watanabe, Takuma Yoshida, Risa Bandou, Tomo Daidoji, Yoshito Itoh, Takaaki NakayaClinical Infectious Diseases, ciaa1517, https://doi.org/10.1093/cid/ciaa1517 Published: 03 October 2020

2. Guardian: Coronavirus outbreakHands. Face. Space’: UK government to relaunch Covid-19 slogan.

3. Fox News: The coronavirus can survive on skin for this many hours, study suggests
Researchers found that SARS-CoV-2 outlived the influenza A virus on human skin
. Madeline Farber By Madeline Farber | Fox News

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.
The views expressed in this blog represent the author’s views held at the time of drafting the blog and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

Does intensive follow benefit Bowel cancer patients?

Photo by rawpixel.com on Pexels.com

The old adage “prevention is better than cure” is mostly true with regards to cancer if you can do it.

If you can’t prevent it , at least catch it early, has been the prime motive behind screening tests for breast, cervical, bowel, lung and prostate cancers. (“early is better”). Cancers that are detected at an early stage can offer a better chance of curative treatment.

So one might logically expect that intensive monitoring and early diagnosis of a cancer relapse or a secondary cancer after initial treatment can be immensely helpful.

But the evidence for intensive hospital follow-up visits and investigations is weak for most cancers except for some cancers such as Testicular Cancers which are highly curable.

Intensive monitoring after bowel cancer treatment can detect treatable cancers. To confirm the benefit of early detection of relapse by intensive monitoring , a trial was conducted comparing intensive follow up versus routine follow up ( in France and Belgium).

Data presented at ESMO ( European Society of Medical Oncology) shows that the intensive follow with scans can detect cancer recurrences which can be treated by further surgery. But unfortunately the intensive follow up did NOT lead to longer life expectancy.

The results might be counterintuitive but after an average follow up more than six years, this trial demonstrates that intensive follow is NOT always best. Scans might be done for psychological reassurance but they could end up causing significant anxiety.

When there are resource constraints (e.g low economic countries) , one has to be careful about frequents routine scans for those without symptoms.

During COVID-19, even in rich countries such as UK where there might be huge waiting lists, one has to consider prioritising scans for those who need most.

References

1. ESMO Daily reporter: INTENSIVE FOLLOW-UP INCREASES FREQUENCY OF CURATIVE INTENT SECONDARY SURGERY IN COLORECTAL CANCER.

2. DRE is useless for follow up of prostate cancer patients. https://www.bmj.com/rapid-response/2011/11/03/dre-useless-follow-prostate-cancer-patients

3. Cancer patients follow up and a new role for GPs. https://www.bmj.com/rapid-response/2011/11/03/cancer-patients-follow-and-new-role-gps

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of drafting the blog and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

How should a doctor treat when evidence is uncertain?

Medicine is not always straight forward.

Photo by rawpixel.com on Pexels.com

Treatment of patients is often guided by evidence. Lot of medical treatments are logical and evidence for effectiveness is straightforward .

But sometimes evidence is patchy and uncertain. Sometimes doctors rely on experience and intuition.

From an ethical point, it might be helpful for doctors to think what would they do when they or their family are in the situation of their patient. Putting oneself in the shoes of the patient can sometimes help to deal with ethical dilemmas.

But some argue that doctors putting themselves in the shoes of patients is not ideal as emotions can cloud judgement.

What do you think?

Please read the BMJ article and my response.

On emotions and clinical judgment” has now been published online by BMJ.
Access the article at: http://bmj.com/cgi/content/full/bmj.m3723
Toll-free link:
http://bmj.com/cgi/content/full/bmj.m3723?ijkey=kWmoDxrWgKLTjgp&keytype=ref

Morgan M. Matt Morgan: Standing in the shoes of a relative may complicate decision making. BMJ2020;370:m3344.doi:10.1136/bmj.m3344 pmid:32873585FREE Full TextGoogle Scholar

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of drafting the blog and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

Once a week chemotherapy is not superior to Chemotherapy given once every 3-weeks

Advanced ovarian cancer is treated by chemotherapy. A pre ious study of Japanese ovarian cancer patients RT showed significantly increased survival in those treated with dose-dense weekly paclitaxel compared to the standard three-weekly schedule.

Data from an international trial called ICON8 was presented at the ESMO Virtual Congress 2020, this week.

The final analysis of ICON8 “provides conclusive evidence that although weekly dose-dense chemotherapy can be successfully administered as first-line treatment for ovarian cancer, it has no survival advantage over the standard chemotherapy given once every 3 weeks.

ICON8: Overall survival results in a GCIG phase III randomised controlled trial of weekly dose-dense chemotherapy in first line epithelial ovarian, fallopian tube or primary peritoneal carcinoma treatment. Citation. Annals of Oncology (2020) 31 (suppl_4): S551-S589. 10.1016/annonc/annonc276

ESMO Daily Reporter: OVARIAN CANCER: FIRST-LINE DOSE-DENSE CHEMOTHERAPY IS NOT SUPERIOR TO STANDARD 3-WEEKLY CHEMOTHERAPY.

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of drafting the blog and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

Olaparib, as a 3rd line treatment, improves survival of a subset of prostate cancer patients with certain genetic changes .

Some prostate cancers are inherited. Some of these cancers have changes in a gene called BRCA.

Some prostate cancers which are not inherited can sometimes have these BRCA changes as well.

Data presented at ESMO ( European Society of Medical Oncology) shows that the prostate cancers with BRCA gene changes derive the most benefit from Olaparib. When administered as a third line treatment ( after failure hormone injection, novel hormonal tablets and chemotherapy) , Olaparib makes these patients live longer.

ESMO Daily Reporter. PROFOUND: OVERALL SURVIVAL DATA WITH OLAPARIB HERALD PRACTICE-CHANGING TREATMENT OF METASTATIC PROSTATE CANCER.

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of drafting the blog and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

Immunotherapy not highly effective in Ovarian cancers

Immunotherapy has made a significant difference to the lives of many cancer patients with Skin, Kidney, Bladder and Lung cancers.

But in ovarian cancer patients, the results of trials have been disappointing .

Data presented at ESMO ( European Society of Medical Oncology) shows that the Immunotherapy agents Pembrolizumab and Nivolumab do not make significant difference over and above chemotherapy.

A caveat though, patients who responded to Nivolumab has longer duration of response and Nivolumab was well tolerated. So this indicates a subset of patients may benefit from chemotherapy.

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of drafting the blog and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

New treatment combination for advanced Kidney cancers

The treatment of kidney cancer has dramatically changed in the last decade. More treatments are in pipeline and there was more exciting news this week.

Upfront immunotherapy in combination with other agents is very promising in 1st line treatment of advanced kidney cancers.

Data presented at ESMO ( European Society of Medical Oncology) shows that the combination of Nivolumab and Cabozantinib is better than Sunitinib alone.

Nivolumab and Cabozantinib” combo joins the other combos “Nivolumab and Ipililumab” and “Pembrolizumab and Axitinib “ as 1st line options

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of drafting the blog and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

Cancer and COVID-19

Cancer patients, as expected, did badly during the 1st wave of the COVID-19 pandemic

Data presented at ESMO ( European Society of Medical Oncology) shows that Cancers had – higher rates of Hospitalisation, higher risk of Complications and increased risk of Death.

Elderly cancer patients on the whole did very badly but surprisingly cancer patients under age of 50 did far worse than their peers without cancer.

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of drafting the blog and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

Immunotherapy not superior to Chemotherapy in 1st line treatment of bladder cancer

Immunotherapy has revolutionised the treatment of many advanced cancers such Skin cancer Melanoma and Kidney cancers.

Immunotherapy is a standard treatment for 2nd line treatment of bladder cancer.

Two recent trials presented at ESMO virtual meeting explored the use of immunotherapy in 1st line setting. (Pembrolizumab and Durvalumab).

Immunotherapy alone, or in combination with Chemotherapy was not superior even in patients selected by markers thought to favour immunotherapy alone.

For most bladder cancer patients immunotherapy remains a excellent 2nd line option or as a maintenance treatment option.

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you. The views expressed in this blog represent the author’s views held at the time of drafting the blog and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

New treatment for Advanced Uterine Cancer

Women with advanced uterine / endometrial cancer are usually treated with chemotherapy.

Those who failed chemotherapy or those who are fit for chemotherapy are sometimes treated with hormone treatment.

Letrozole is one such hormone treatment for those patients with hormone sensitive cancer.

In breast cancer, Letrozole efficacy can be improved by a treatment called Palboclicib.

A trial was done to check whether the same improvement can be observed in uterine cancer when the combination of Letrozole and Palboclicib is tried.

The trial data presented at the ESMO ( European Society of Medical Oncology) is very promising.

If large trials confirm this finding, the combination would be standard treatment in future.

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of drafting the blog and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

Do soft drinks increase the risk of an early death?

Yes.

Soft drinks do increase risk of an early death.

In a large study involving 451 743 individuals from 10 countries in Europe, the regular consumption of soft drinks increased the risk of death.

The increased risk was seen with both sugared drinks as well as artificially sweetened drinks. Worryingly the hazard from artificially sweetened drinks seems higher.

The take home message: drink more water !

References

1. JAMA . Association Between Soft Drink Consumption and Mortality in 10 European Countries. JAMA Intern Med. Published online September 3, 2019. doi:10.1001/jamainternmed.2019.2478.

2. Daily Mail. Just TWO glasses of diet drinks each day may raise the risk of an early death, reveals study by the World Health Organisation.

3. The Guardian. Soft drinks, including sugar-free, linked to increased risk of early death.

Can Hair dyes cause cancer?

Yes, there is a possible increased risk of some types of skin and breast cancer as well as ovarian cancer.

Permanent hair dyes are widely used. A recent study published in BMJ suggests that use of Hair dyes might be risky.

This large study from United States enrolled 117 200 women in the Nurses’ Health Study. The women reported on personal use of permanent hair dyes, and were followed for 36 years. So overall it is a high quality observational study.

Read the full paper and Caveats at the BMJ website.

References

Personal use of permanent hair dyes and cancer risk and mortality in US women: prospective cohort study

BMJ 2020; 370 doi: https://doi.org/10.1136/bmj.m2942 (Published 02 September 2020)

Cite this as: BMJ 2020;370:m2942

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of drafting the blog and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

How to avoid catching Coronavirus indoors during the winter months?

At Offices and Shops, Ventilation is the Key.

If enough fresh air comes through and filters in Air conditioning units are serviced properly risks are manageable.

It could be risky if Ventilation is bad in large offices and Shops where is lot of people going in and out.

One infected person can easily spread to many other people if air is stuffy and stale and fresh air is not coming in to dilute the virus !

In private homes, where only family members are present, it is likely to be safe as long as a everyone of feeling well.

References

BBC news. Covid-19: Five ways to avoid catching the virus indoors. By David Shukman. BBC News science editor. Aug 2020.

CDC. Employer Information for Office Buildings.

WHO. Q&A: Ventilation and air conditioning in public spaces and buildings and COVID-19.

HSE. Air conditioning and ventilation during the coronavirus outbreak.

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of drafting the blog and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

Is Honey a better treatment for coughs and colds ?

Possibly yes, in some cases of viral infections , according to a paper published a BMJ group journal ( BMJ Evidence Based Medicine) .

The paper has been widely quoted in various newspapers today.

The BMJ group journal authors report: “Honey was superior to usual care for the improvement of symptoms of upper respiratory tract infections.

It provides a widely available and cheap alternative to antibiotics…….but further high quality, placebo controlled trials are needed.”

A word of caution: Honey has high sugar content. Diabetics need to be careful. People will allergies need to take care. Of course bacterial infections need antibiotics particularly in old and vulnerable!

References

1. BMJ Evidence Based Medicine. Effectiveness of honey for symptomatic relief in upper respiratory tract infections: a systematic review and meta-analysis .

Abuelgasim H, Albury C, Lee J Effectiveness of honey for symptomatic relief in upper respiratory tract infections: a systematic review and meta-analysis BMJ Evidence-Based Medicine Published Online First: 18 August 2020. doi: 10.1136/bmjebm-2020-111336.

2. Guardian Newspaper:

3. Daily Mail.

4. BBC paper review .

5. Evening Express

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of publication and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

Is weight loss a sign of cancer?

If you have been dieting and exercising to shed excess weight, then you can celebrate your success in achieving your goal.

But some poorly lose weight unintentionally . This type of weight loss that occurs without intention might be of concern in some people.

A recent article in BMJ advocates screening for cancer in some patients if they have weight loss and other symptoms in their chest and abdomen.

Male smokers over the age of 50 are one of the high risk groups !

Don’t ignore weight loss !

References

Prioritising primary care patients with unexpected weight loss for cancer investigation: diagnostic accuracy study

BMJ 2020; 370 doi: https://doi.org/10.1136/bmj.m2651 (Published 13 August 2020)

Cite this as: BMJ 2020;370:m2651

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of publication and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

Are Routine blood tests essential during follow up of low grade Lymphoma?

Bloods tests have the potential to pick up various abnormalities including cancer related abnormalities during follow up of cancers.

But , many patients would be surprised to know that there is ongoing debate about usefulness of routine blood tests atleast in some cancers !

In a recent study, Australian investigators assessed the role of routine blood tests during monitoring of patients with low grade lymphoma.

They found that routine blood tests rarely found or detected disease progression in patients who did not have any symptoms.

References

Routine Blood Tests in Asymptomatic Patients With Indolent Lymphoma Have Limited Ability to Detect Clinically Significant Disease Progression. DOI: 10.1200/JOP.19.00771 JCO Oncology Practice – published online before print June 25, 2020. PMID: 32584701

Effectiveness of Routine Blood Testing in Detection of Disease During Active Surveillance for Indolent Non-Hodgkin Lymphoma. By Matthew Stenger. Posted: 7/16/2020 1:40:00 PM . Last Updated: 7/29/2020 1:59:00 PM

Utility of Routine Surveillance Laboratory Testing in Detecting Relapse in Patients With Classic Hodgkin Lymphoma in First Remission: Results From a Large Single-Institution Study. DOI: 10.1200/JOP.19.00733 JCO Oncology Practice – published online before print May 5, 2020. PMID: 32369413

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of publication and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

Can a Protein rich diet lead to a longer life ?

Yes, a protein rich diet can lead a longer life and reduce risk deaths due to heart diseases.

Before you rush to relish your burger or steak , please note the evidence for beneficial effect is very much in favour of plant proteins than animal proteins.

So Befriend your Beans !

And Love your Lentils !

Reference

Dietary intake of total, animal, and plant proteins and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of prospective cohort studies

BMJ 2020; 370 doi: https://doi.org/10.1136/bmj.m2412 (Published 22 July 2020)

Cite this as: BMJ 2020;370:m2412

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of publication and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

Health effects of vitamin and mineral supplements

In Western countries, upto two thirds of people take vitamin and mineral supplements regularly.

Many people think it’s common sense to take supplements. Many people don’t realise mega doses of vitamins can cause harm. Paradoxically the people who don’t have a healthy diet are less likely to supplements than those who have a well balanced diet.

A recent article in BMJ reviews the evidence regarding “Health effects of vitamin and mineral supplements” and concludes that “Randomised trial evidence does not support use of vitamin, mineral, and fish oil supplements to reduce the risk of non-communicable diseases”.

This article is certainly a “food for thought”

Reference

Food for Thought 2020. Health effects of vitamin and mineral supplements. BMJ 2020; 369 doi: https://doi.org/10.1136/bmj.m2511 (Published 29 June 2020). Cite this as: BMJ 2020;369:m2511

Skeie G, Braaten T, Hjartåker A, et al. Use of dietary supplements in the European Prospective Investigation into Cancer and Nutrition calibration study. Eur J Clin Nutr2009;63(Suppl 4):S226-38. doi:10.1038/ejcn.2009.83 pmid:19888276

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of publication and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

Dexamethasone: “There’s Lot more Life in that Old Dog Yet”

Dexamethasone is one of the commonly used steroids in Clinical practice. It is used to treat allergies; it is used as an anti-inflammatory drug for all sorts of inflammation affecting various part of body.

In cancer patients, Dexamethasone is certainly used widely. It is used as an anti-sickness drug, appetite stimulant, to reduce swelling around brain tumours, and as an anticancer drug in Prostate cancer.

Dexamethasone has now found to be useful in treatment of Corona Virus infection.

In one of the largest Covid-19 trial, the RECOVERY trial- this low cost drug has been found to improve survival of patients particularly those who need Ventilation.

A word of caution though, it did not benefit patients with mild infection due to Coronavirus.

References:

Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of publication and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

New medication for prostate cancer

The Male hormone- Testosterone feeds the prostate cancer. Shutting down testosterone production in men can help to control prostate cancer.

Advanced prostate cancer is currently treated first by regular hormone injections.

The hormone injections reduce the Testosterone in men.

Now a new medication, called Relugolix, has been successfully tested in clinical trials. Relugolix, unlike other first line hormone injections , can be taken by mouth instead.

Relugolix also has the advantage of not only working rapidly but also has the advantage of stopping to work quickly when it is withdrawn. This is unlike the injections which take a while to work but also do not stop working quickly when injections are stopped.

References

NEJM. Oral Relugolix for Androgen-Deprivation Therapy in Advanced Prostate Cancer

Neal D Shore et al. N Engl J Med. 2020.

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of publication and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

Can Vitamin K help fight Coronavirus?

Possible but like every other observational study, take it with pinch of salt.

Further evidence from well conducted trials are needed before it can be recommended as a COVID treatment.

In mean time, it’s better to stick to natural sources of vitamin such as those mentioned in the newspaper article ( spinach, broccoli, green vegetables, blueberries, all types of fruit and vegetables).

Guardian Newspaper: Vitamin K could help fight coronavirus, study suggests

Scientists in Netherlands explore possible link between deficiency and Covid-19 deaths

Daniel Boffey. Fri 5 Jun 2020 14.50 BST

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of publication and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

Does Eating Eggs lead to Heart problems?

No, Eating Eggs in moderation is not associated with increased Heart problems.

Heart diseases are one of major killers in Men and Women. In the past, Cholesterol was exclusively blamed for most of the Heart problems. Nowadays, such a simplistic view has been abandoned. We now know that Heart diseases are due to a complex set of poor diet and life style.

Previously Eggs which have lot of dietary cholesterol have been subject to lot of bad press.

A recent pooled analysis of good quality data shows that ” moderate egg consumption (up to one egg per day) is not associated with cardiovascular disease risk overall, and is associated with potentially lower cardiovascular disease risk in Asian populations.”

So like everything else with regards to diet , moderation is the way to go !

Reference

Egg consumption and risk of cardiovascular disease: three large prospective US cohort studies, systematic review, and updated meta-analysis

BMJ 2020; 368 doi: https://doi.org/10.1136/bmj.m513 (Published 04 March 2020)

Cite this as: BMJ 2020;368:m513

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Does air pollution in cities make your jogging and walking less beneficial ?

Yes, air pollution is now being recognised as an important cause of death in major cities and towns.

So avoid major roads and very busy streets.

Any benefit you might accrue from exercise can be wiped out by heavy air pollution if you are jogging on a heavily congested road.

References

1. Telegraph: Pollution wipes out the benefits of exercise, study suggests

2. BMJ . Air pollution. Short term exposure to fine particulate matter and hospital admission risks and costs in the Medicare population: time stratified, case crossover study

BMJ 2019; 367 doi: https://doi.org/10.1136/bmj.l6258 (Published 27 November 2019)

3. Telegraph. Does exercising in pollution do you more harm than good?

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Acupuncture for Migraine

Can Acupuncture help migraines?

Yes, says a Chinese trial published in British Medical Journal .

Many complementary and Alternative therapies have very thin evidence base ( if all present ).

The researchers are to be congratulated for doing a randomised trial and publishing results in a peer reviewed medical journal

References

Manual acupuncture versus sham acupuncture and usual care for prophylaxis of episodic migraine without aura: multicentre, randomised clinical trial

BMJ 2020; 368 doi: https://doi.org/10.1136/bmj.m697 (Published 25 March 2020)

Cite this as: BMJ 2020;368:m697

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Is it worthwhile to be on constant vigilance for any symptoms which might indicate cancer has come back ?

Unfortunately no.

A Cancer charity advices to watch out for symptoms.

Constant Vigilance for cancer recurrence has its own downsides.

After successful cancer treatment, being on look out for symptoms constantly wrecks your quality of life for minimal benefit in most cases.

Many trials of intensive screening shown no benefit for early detection of secondary cancer. ( note- this is different from the ongoing debate about benefits of primary cancer detection with cancer screening programs such as Mammograms, PSA screening, bowel cancer screening).

Cancer patients are quite often aware of own body and pre-existing aches and pains.

The best thing is to act promptly if there are “any new and persistent symptoms” . For vast majority of cancer patients, there is no need to do a frequent check list of possible symptoms, on a daily or weekly interval.

Do NOT be on constant vigilance for all possible cancer symptoms unless you have been specifically advised to do so by your oncology team.

Eternal Vigilance for months and years can wreck your quality of life.

Think Positive. Nothing is lost when you maintain hope.

References

BBC news . https://www.bbc.co.uk/news/health-49999404

‘Unacceptable’ delays in diagnosing secondary breast cancer

The standard disclaimer is very relevant to this blog.

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Can Vitamin D protect against respiratory infections ?

Can Vitamin D protect against Respiratory infections ?

The answer is yes, according a paper published in the BMJ ( British Medical Journal) in the recent past.

With Corona Virus ( COVID 19) pandemic raging in Europe and USA, there is lot of interest in treatment and naturally prevention of Respiratory tract infections.

It is also understandable why a paper published in Feb 2017 is one the most read BMJ paper in March 2020.

The paper analysed data from “25 eligible randomised controlled trials involving a total of 11 321 participants”.

The study concludes ” Vitamin D supplementation was safe and it protected against acute respiratory tract infection overall. Patients who were very vitamin D deficient and those not receiving bolus doses experienced the most benefit.”

References

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

BMJ 2017; 356 doi: https://doi.org/10.1136/bmj.i6583 (Published 15 February 2017)

Cite this as: BMJ 2017;356:i6583

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Plain English Medical Letters to Patients

Writing letters to patients in plain English without medical jargon is a gift that only a few doctors possess.

Personalising complex medical terminology in a letter dictated over a few minutes is NOT an inherent skill possessed by many doctors including those who are native English speakers.

Dictating Plain English medical letters would take considerable time and effort – particularly if letters are going to succinctly summarise everything from a medical consultation.

In UK, with regards to Cancer, we are lucky to have cancer charities who do a good job of providing information in plain English ( E.g Cancer Research UK, Macmillan Cancer Support, Prostate Cancer UK).

Cancer Patients in UK also have the support of Cancer Nurse Specialists ( CNS ) who do a fantastic job of guiding patients through their cancer journey and clarify all medical jargon to patients.

Other specialities might not have the resources that are available to cancer patients. But, on the whole, Clinic Time slots are precious. Many UK specialists have long waiting lists.

So if further time and effort is to be expended in busy clinics for dictating plain English Letters – in addition to the usual Medical letters to GP – good clinical evidence is needed to demonstrate that separate plain English letters do benefit patients in a meaningful way.

Please do read the BMJ article and put forward your views in the rapid response section.

Access the article at: http://bmj.com/cgi/content/full/bmj.m949

Toll-free link:
http://bmj.com/cgi/content/full/bmj.m949?ijkey=nxJ9CdIVHKZW1Jd&keytype=ref

Disclaimer:

The views expressed here are my personal views and do not represent the views of any other professional organisation I am associated with…

Chemotherapy for Elderly Prostate Cancer patients with Advanced prostate cancer

Chemotherapy has been shown to unequivocally improve prognosis of advanced prostate cancer patients.

The survival was found to be improved by an average of 10 months with addition of chemotherapy to long term hormone therapy in a large clinical trial.

Prognosis without chemotherapy was 71 months and prognosis with chemotherapy was 81 months.

But this extra benefit from chemotherapy comes at a cost.

Chemotherapy can be toxic with occasional life threatening side effects. Some elderly patients are frail and others may have diseases affecting heart, lung and brain.

So some patients after carefully weighing up benefits and risks might decline chemotherapy.

This need to weigh up risks and benefits is sometimes very difficult for both patients and doctors before a decision is reached whether to opt for chemotherapy or not.

Express your views at the BMJ rapid response section.

References

Access the BMJ article at: http://bmj.com/cgi/content/full/bmj.m519

Toll-free link:
http://bmj.com/cgi/content/full/bmj.m519?ijkey=Nj2sM5GVE36Yq8G&keytype=ref

Do omega 3 supplements provide protection from Stroke and Heart diseases?

It is a common belief that omega 3 fatty acids provide protection from strokes and heart attacks, and improve overall health.

A review from the esteemed Cochrane collaboration pours cold water on this belief.

The review concludes that omega 3 provides ” little or no meaningful effect on the risk of death from any cause”.

They conclude that “omega 3 supplements probably makes little or no difference to risk of cardiovascular events, coronary heart deaths, coronary heart disease events, stroke or heart irregularities”.

The review did find “moderate evidence that ALA, found in plant oils (such as rapeseed or canola oil) and nuts (particularly walnuts) may be slightly protective of some diseases of the heart and circulation”.

However, the effect was very small. They estimated that “143 people would need to increase their ALA intake to prevent one person developing arrhythmia”.

They also estimated that “One thousand people would need to increase their ALA intake to prevent one person dying of coronary heart disease or experiencing a cardiovascular event”.

Overall the review finds that overall “omega 3 provides little if any benefit at all”.

References

New Cochrane health evidence challenges belief that omega 3 supplements reduce risk of heart disease, stroke or death.

Cochrane Database of Systematic Reviews 2018, Issue 7. Art. No.: CD003177. https://www.cochrane.org/CD003177/VASC_omega-3-intake-cardiovascular-disease

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Walking is good exercise

New year. January. First month of a New year – it’s the time of year many people take a look at their lifestyle and vow to eat better, exercise better and live better.

Many people consider Gym or Health Club membership.

But Exercise doesn’t need to cost a lot. Being active, doesn’t need to be regimented.

Simply walking anywhere is good compared to no exercise at all. Walking in the Park or Quiet streets has lot of benefits.

Good article in BBC on the benefits of walking.

A word of caution though !

Avoid Walking or Jogging near busy roads so that the benefits of walking are not negated by pollution.

Reference

1. BBC. 8 reasons why we should all walk more. BBC.

2. Guardian. Traffic fumes in city streets ‘largely wipe out exercise benefits for over-60s’.

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Exciting new immunotherapy treatment !

Test tube lab

The holy grail of cancer treatment is design a drug that is highly lethal to cancerous tissue but completely spares the normal tissues.

Scientists at Cardiff University have discovered immune cells which could provide such a clever treatment.

It is still early days. The principle has been proven in lab. But to be a useful treatment that can be used in cancer patients, it is still far off.

This particular novel form of immunotherapy using T cells is still in early stages and so many hurdles have to be overcome before this discovery could be employed in cancer treatment.

Nevertheless, it has certainly excited many researchers in the field of cancer and the paper has been published by a premier scientific journal.

 

References:

Original scientific paper. Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

BBC news. Immune discovery ‘may treat all cancer’. By James Gallagher. Health and science correspondent

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Do the morning people have it all ?

Picture of morning bird against rising sun

There is definitely truth in idiom that “The early bird catches the worm”.

Are there any other life advantages for the early risers compared to those who hate early mornings?

A paper in BMJ says the women with “morning preference” have less risk of breast cancer compared to the evening people.

So there are advantages for those who can jump out of their bed easily in the morning but it is a different question whether the late risers can train themselves to be early risers !

Reference

Investigating causal relations between sleep traits and risk of breast cancer in women: mendelian randomisation study

BMJ 2019; 365 doi: https://doi.org/10.1136/bmj.l2327 (Published 26 June 2019)

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Does alcohol increase of breast cancer?

Yes, Alcohol does substantially increase the risk of Breast cancer.

Very few people seem to be aware of the risks.

Previously it was thought that heavy drinking is responsible for harmful cancer effects.

But studies from U.K and U.S.A have subsequently shown that even light to moderate drinking can increase the risk of breast cancer.

A very large study involving more than 1,250,000 middle-aged women in the United Kingdom ( enrolled in the Million Women Study) showed that “Low to moderate alcohol consumption” in women increases the risk of breast cancer and certain other cancers.

In a study involving more than 88,000 women from United States, also showed that light to moderate drinking increases the risk of breast cancer.

So keep counting the alcohol units during the festive time.

References

1. U.K. Study: Moderate alcohol intake and cancer incidence in women.

2. U.S.A study. Light to moderate intake of alcohol, drinking patterns, and risk of cancer: results from two prospective US cohort studies. BMJ 2015; 351 doi: https://doi.org/10.1136/bmj.h4238 (Published 18 August 2015). Cite this as: BMJ.2015;351:h4238

3. Telegraph. Drinking alcohol raises risk of cancer by snapping DNA, scientists find.

4. Telegraph U.K. Just one in five women at risk of breast cancer know alcohol increases the danger.

Is whole milk harmful ?

In years gone by , many viewed milk as a wholesome healthy food. Government encouraged consumption of milk by providing free milk.

But in recent years, milk is viewed with suspicion.

Vegans shun milk and diary products.

Perhaps the Vegans got it right all along at least as far as whole milk is concerned.

A very large study involving 168 153 women and 49 602 men was published recently in British Medical Journal. The study found that whole milk intake is associated with increased risk of death from heart problems and from some cancers such as lung cancer, ovarian cancer, and prostate cancer.

Interestingly “Cheese and yogurt intake was NOT associated with increased risk of death”.

The risk was also less with “skimmed or low fat milk”.

References

1. Government Cheap Milk Scheme. Br Med J 1940; 2 doi: https://doi.org/10.1136/bmj.2.4170.806-b (Published 07 December 1940)

2. Vegetarian diets. BMJ 2009; 339 doi: https://doi.org/10.1136/bmj.b2507 (Published 08 July 2009)

3. Associations of dairy intake with risk of mortality in women and men: three prospective cohort studies. BMJ 2019; 367 doi: https://doi.org/10.1136/bmj.l6204 (Published 27 November 2019). Cite this as: BMJ 2019;367:l6204

Futile antibiotic treatments

Infections are normally highly treatable with antibiotics.

But when someone is dying , the body’s immune system gets weaker. Hence infections quite often occur as part of the dying process.

Treating these infections are often futile. But human nature is inclined to “fight and survive” by all means. So quite often powerful antibiotics are used to treat these infections in dying patients.

There is an ethical argument against futile treatments.

There is also the risk of antibiotic resistance in general population if antibiotics are used inappropriately.

Submit your views at BMJ journal website (rapid response section).

References

Access the article at: http://bmj.com/cgi/content/full/bmj.l6706

Toll-free link:

http://bmj.com/cgi/content/full/bmj.l6706?ijkey=ZXN1zz6QXpPz8np&keytype=ref

Can long working hours kill you?

Yes, it can.

It has been well established by systemic review that working long hours can lead to excessive heart attacks. ( ref 1).

A recent French study indicates that working long hours can lead to increased risk of stroke ( Long hours defined as more than 10 hours on at least 50 days per year in this study) (ref 2).

So look after yourself and don’t push yourself too hard !

References

1. Long Working Hours and Coronary Heart Disease: A Systematic Review and Meta-Analysis .

2. Long working hours ‘linked to stroke risk’ BBC News.

Can complementary therapies do harm ?

Yes,

Very interesting program on BBC “Vitamins and Green Tea” broadcast by BBC . ( BBC iPlayer).

Another Good article on BBC website: Complementary cancer therapies ‘do more harm than good’

So everything in moderation if necessary and take only that’s appropriate for your individual circumstances!!!

 

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Are some people fat because of their “gut bacteria mix” is of the wrong sort?

Some people are able to eat everything they like and do not gain much weight (as long as they don’t go over the top).

But others have to just smell a chocolate or a cake and they put on weight (even though this comment is made jokingly some people are so exasperated with their weight gain in-spite of all diets !!!).

Could this discrepancy be related to the having “wrong cocktail of Bacteria in their gut”.

Some scientists seem to think so. An intriguing proof of concept study has been published in Nature Medicine which is a very esteemed science journal.

Read this thoroughly interesting and balanced article on The Atlantic website.

References

The Fundamental Link Between Body Weight and the Immune System

JAMES HAMBLIN

AUG 2, 2019

Inflammation plays a critical role in determining how we digest food, and it’s only now starting to reveal itself.

Can stress cause infection?

Yes, stress can increase risk of serious infections.

Based on personal experience, anecdotally many people would vouch for the fact that stressful events makes them more prone to illness. But strong scientific evidence has been spare.

A recent Swedish study published in British Medical Journal confirms that stress related disorders significantly increase risk of life threatening infections later in life.

Reference

Stress related disorders and subsequent risk of life threatening infections: population based sibling controlled cohort study

BMJ 2019; 367 doi: https://doi.org/10.1136/bmj.l5784 (Published 23 October 2019)

Cite this as: BMJ 2019;367:l5784

Can weather affect joint pain?

Yes, weather can affect joint pain.

A study involving 2500 people conducted by University of Manchester study showed that “people with arthritis feel more pain on humid days”

The study reports that “Damp and windy days with low pressure can increase risk of experiencing more pain than normal”

Cold, damp days also made pain worse but interestingly pain was not made by temperature alone”.

Other studies in the past have also found a “significant correlation between humidity and pain“.

References

BBC News. People ‘more likely to feel pain on humid days’.

Does rheumatoid arthritis disease activity correlate with weather conditions?

The Influence of Weather Conditions on Joint Pain in Older People with Osteoarthritis: Results from the European Project on OSteoArthritis.

“Think Positive “ and live longer !

People with sunny disposition seems to live longer.

Having a positive outlook on life seems to protect heart.

Is it a case of “chicken vs egg” in that what came first. Do healthy people have a optimistic outlook and pessimistic people have lot of social, personal and health problems. Do life problems make people pessimistic or being optimistic makes one do better?

Researchers have adjusted the data for confounding factors. Evidence so far is very intriguing.

And the next question is – can one learn to be optimistic, change personality and have beneficial health effects. We don’t know at present.

References

1. Guardian. Optimists have lower risk of heart problems and early death.

2. Guardian. Optimism may hold secret to longer life, study suggests.

3. The association of optimism and pessimism with inflammation and hemostasis in the Multi-Ethnic Study of Atherosclerosis (MESA)

4. JAMA. Association of Optimism With Cardiovascular Events and All-Cause Mortality

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Crowdfunding expensive stem cell therapies

Crowd fund metaphor

If you have come across a desperate request to crowdfund an expensive stem cell therapy, read this well researched BBC article before you contribute.

Hope is a powerful driver particularly when someone is facing immense difficulties in life. Human beings have a natural inclination to fight against all odds and it seems to be inbuilt in our DNA and psyche.

But not all promising treatments do help desperate people searching for a cure.

Reference.

BBC news. The unwarranted hype of stem cell therapies. By Jules Montague. 21 August 2019

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Dietary advice: take it with a pinch of salt

Official dietary advice as well as various “Diets” promoted by various celebrities tend to be very prescriptive. They often give the impression that the evidence behind everything they promote is very clear cut.

But truth is far more murkier ( I might say more “mish mash “).

A new study analysis of old data comes to a different conclusion about “red meat”. This is in fact not surprising as the evidence for various Dietary guidelines and “Diets” are not usually robust and watertight and involves lot of assumptions.

What is the take home message:

Eat “everything you like” in moderation and try to make it as balanced as possible with substitutes for things you avoid !!

Avoid processed food as much as possible and eat fresh.

Don’t be surprised if the next two studies on this topic reach three different conclusions.

References

1. BBC news. Is red meat back on the menu?

2. New York Times. Eat Less Red Meat, Scientists Said. Now Some Believe That Was Bad Advice.

3. The original study article from Annals of Internal Medicine. Unprocessed Red Meat and Processed Meat Consumption: Dietary Guideline Recommendations From the Nutritional Recommendations (NutriRECS) Consortium.

4. Daily Mail. You DON’T need to cut out red meat: Scientists say official advice on eating less beef, pork and lamb is based on bad evidence and having it four times a week poses ‘NO cancer risk’ 

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Olaparib: exciting results in treatment of prostate cancer harbouring certain genetic alterations

https://www.esmo.org/Oncology-News/Olaparib-Outperforms-Enzalutamide-or-Abiraterone-Acetate-in-Men-with-mCRPC-and-HRR-Alterations

Olaparib is set to become a standard treatment option for advanced prostate cancer patients whose tumours harbour certain genetic alterations.

Study results presented at ESMO congress in Barcelona shows good response to olaparib compared to other hormonal agents in this sub-group of patients.

References

1. ESMO European Society of Medical Oncology Annual Conference 2019. Barcelona. Olaparib Outperforms Enzalutamide or Abiraterone Acetate in Men with mCRPC and HRR Alterations.

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Acknowledgement: Copyright of Slides: Authors and ESMO

Prostate Bed Radiation can be avoided or delayed in many prostate patients following surgery

A large UK trial shows that lot of men undergoing surgery for prostate do not need Immediate follow-on radiation straightaway.

Trial data was presented at ESMO conference in Barcelona.

Radiation can be entirely avoided in many patients at high risk of relapse and it can be safely delayed until there is definite evidence of relapse in selected patients for months and years.

Waiting and watching is certainly prudent in some patients rather than rushing in with radiation so as to avoid side effects.

Combined data analysis using study data from France as well as Australian and New Zealand trials confirm these findings.

References

1. ESMO 2019 Barcelona. Men with Prostate Cancer can be Spared Radiotherapy after Surgery [ESMO 2019 Press Release].

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Veliparib : Another new drug for treatment of Ovarian Cancer

Veliparib trial data has certainly brought more options to the table in treatment of advanced Ovarian cancer.

Trial data presented at ESMO congress at Barcelona shows that first line therapy with Veliparib is beneficial.

Acknowledgement: Copyright of Slides: Authors and ESMO

References

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

New drug combination for Ovarian Cancer (Olaparib and Bevacizumab)

New trial data presented at the ESMO cancer Congress 2019 in Barcelona, Spain, show excellent results for the combination of Olaparib and Bevacizumab. The combination looks likely to become standard of care in at-least a subgroup of patients.

The expert discussing the trial data did raise the possibility that most benefit seems to come from Olaparib in patients with BRCA mutations and whether Olaparib alone instead combination is enough for this group. More data is awaited.

References

1. ESMO 2019 congress press release. Ovarian Cancer: More Women Benefit from Maintenance Combined Targeted Therapy [ESMO 2019 Press Release]

Acknowledgement: Copyright of Slides: Authors and ESMO

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Niraparib : New treatment for new diagnosed Ovarian Cancer

A landmark study presented at ESMO congress at Barcelona shows significant benefits for maintenance treatment with the drug Niraparib.

Niraparib is likely to become a standard treatment in a much more widely group of advanced ovarian cancer patients.

Many clinicians will be weighing up Niraparib Vs Olaparib in Some patients and Niraparib vs Bevacizumab in other groups of patients.

Reference

1. Niraparib Prolongs PFS in Patients with Newly Diagnosed Advanced Ovarian Cancer. ESMO press release.

Acknowledgement: Copyright of Slides: Authors and ESMO

Melanoma Skin cancers: significant improvement in life expectancy with immunotherapy

Advanced melanoma skin cancers used to carry a dismal prognosis.

Data presented at Barcelona European Cancer Congress ( ESMO) shows the prognosis has improved remarkably in the recent years.

Fifty percent of patients are now alive for at-least five years. It is quite a remarkable achievement for immunotherapy.

References

1. ESMO press release. One in Two Patients with Metastatic Melanoma Alive after Five Years with Combination Immunotherapy [ESMO 2019 Press Release].

2.BBC News. Skin cancer: Half of people surviving advanced melanoma. By James Gallagher. Health and science correspondent, BBC News

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.