Are Routine blood tests essential during follow up of low grade Lymphoma?

Bloods tests have the potential to pick up various abnormalities including cancer related abnormalities during follow up of cancers.

But , many patients would be surprised to know that there is ongoing debate about usefulness of routine blood tests atleast in some cancers !

In a recent study, Australian investigators assessed the role of routine blood tests during monitoring of patients with low grade lymphoma.

They found that routine blood tests rarely found or detected disease progression in patients who did not have any symptoms.

References

Routine Blood Tests in Asymptomatic Patients With Indolent Lymphoma Have Limited Ability to Detect Clinically Significant Disease Progression. DOI: 10.1200/JOP.19.00771 JCO Oncology Practice – published online before print June 25, 2020. PMID: 32584701

Effectiveness of Routine Blood Testing in Detection of Disease During Active Surveillance for Indolent Non-Hodgkin Lymphoma. By Matthew Stenger. Posted: 7/16/2020 1:40:00 PM . Last Updated: 7/29/2020 1:59:00 PM

Utility of Routine Surveillance Laboratory Testing in Detecting Relapse in Patients With Classic Hodgkin Lymphoma in First Remission: Results From a Large Single-Institution Study. DOI: 10.1200/JOP.19.00733 JCO Oncology Practice – published online before print May 5, 2020. PMID: 32369413

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only and do check the the sources where cited. Please consult your own doctor to discuss concerns and options relevant to you.

The views expressed in this blog represent the author’s views held at the time of publication and is likely to change overtime, particularly when new evidence comes to light. The blog is not necessarily endorsed by any organisation the author is associated with and views are not substitute for professional advice.

Blaming the tools

Tools

Any one from any trade would be expected to use the tools of the trade appropriately.

Tweaking the tools unnecessarily or blaming the tools if things do not pan out as planned is generally frowned upon .

Same with medical professionals !

Please contribute your thoughts at BMJ rapid response page.

Interpreting test results: dont blame the tools

Access the article at: http://bmj.com/cgi/content/full/bmj.m1162

Toll-free link:
http://bmj.com/cgi/content/full/bmj.m1162?ijkey=sZarWS4YlJf9NS0&keytype=ref

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Crowdfunding expensive stem cell therapies

Crowd fund metaphor

If you have come across a desperate request to crowdfund an expensive stem cell therapy, read this well researched BBC article before you contribute.

Hope is a powerful driver particularly when someone is facing immense difficulties in life. Human beings have a natural inclination to fight against all odds and it seems to be inbuilt in our DNA and psyche.

But not all promising treatments do help desperate people searching for a cure.

Reference.

BBC news. The unwarranted hype of stem cell therapies. By Jules Montague. 21 August 2019

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

What’s in a name?

awareness cancer design pink Photo by Miguel on Pexels.com

The word cancer is a dreaded one. Not without a good reason. Cancer is the number one killer. Even when someone has a good outcome, the cancer journey is torture. Emotional turmoil is immeasurably horrendous.

But many people would be surprised to hear that there exists a category of low risk cancers. “Low-risk Cancers are cancers which usually don’t kill; These Cancers are found either incidentally on scans performed for some other reasons or found as part of routine cancer screening.”

Because they are not deadly, Should the patients diagnosed with low-risk cancers be spared the dreaded label of cancer?

Should low-risk cancers be labelled something else and the word cancer used only for the “serious” high-risk cancers ?

Personally, I do not agree with renaming of the low risk cancers..Others disagree

Joint the debate at the BMJ.

Submit your views through rapid response

Reference: 
Should we rename low risk cancers? BMJ

several assorted color tags Photo by rawpixel.com on Pexels.com

Are Vitamin and Food supplements safe and helpful?

 

medical tablets pharmacy cure

Photo by Pixabay on Pexels.com

 

A British man recently ended up needing a liver transplant after taking green tea capsules. (1).(2).

Many people do not realise that supplements can be useless or even harmful. 

Firstly, Dietary supplements may not always be helpful. Even though the Public Health team in England recommend vItamin D supplements, a large study published recently  – found that Vitamin D supplements do NOT prevent fractures or falls in General population. (3) (4).

Secondly, Dietary supplements can be harmful. For example , a cancer prevention trial involving 35,533 North-American men reported that  “Dietary supplementation with vitamin E significantly increased the risk of prostate cancer among healthy men”. (JAMA 2011; 306: 1549).  Another cancer prevention trial in Finland involving 29,133 male smokers unexpectedly found a “higher incidence of lung cancer among the men who received beta carotene dietary supplements”. (NEJM 1994;330:1029 )

On the other hand, Vitamin are essential nutrients. Vitamin deficiency can be severely harmful to health. Vitamin D deficiency is common in colder parts of northern hemisphere. Vitamin D supplements are used in treatment and prevention of osteoporosis (5). Vitamin B12 deficiency is common in Vegans and Vitamin B12 supplements are used. (6).

So there is no clear cut answer ….

Always consider the possibility that “dietary supplements may actually have harmful as well as possible beneficial effects”. 

yellow health medicine wellness

Photo by Pixabay on Pexels.com

References: 

  1. BBC News – Are supplements safe and do they work? https://www.bbc.com/news/health-45992725
  1. Daily mail: Green tea supplements may cause liver damage, warns EU watchdog. https://www.dailymail.co.uk/health/article-5629791/How-healthy-healthy-EU-warns-green-tea-supplements.html
  1. Public Health England recommends vitamin D supplements in autumn and winter.  BMJ 354 doi:10.1136/bmj.i4061
  1. Guardian : Vitamin D supplements don’t help bone health, major study concludes. https://www.theguardian.com/society/2018/oct/04/vitamin-d-supplements-dont-help-bone-health-major-study-concludes
  1. Vitamin B12 and Health: http://www.lnds.nhs.uk/Library/Vitamin_B12_and_HealthOct2018LNDS123.pdf
  1. National Osteoporosis Guideline Group: https://www.sheffield.ac.uk/NOGG/mainrecommendations.html

How to communicate that the disease is mild even though symptoms are disabling?

women s white long sleeved top

Beth McHugh makes a strong argument for doctors “not to explicitly discuss disease severity scale”.

But

(1) A valid informed consent would then become difficult

(2) Not discussing severity, is not a practical option for patients with certain illness.

My BMJ eLetter on this topic…

Risk categorisation will continue to be the norm in future as genomic data leads to personalised medicine.

England’s 100 000 Genomes Project