Can Vitamin D control prostate cancer?

Vitamin D is also known as the “sunshine vitamin” because it’s produced in your skin in response to sunlight. Vitamin D is critical for bone health and general health.

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Low levels of vitamin D in blood have been linked to cancer and other diseases.

But taking Vitamin D supplements to control an existing prostate cancer is controversial.

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In  the lab, Vitamin D can stop prostate cancer cells growing and spreading.

One human trial suggested better outcome when high strength vitamin D is combined with standard chemotherapy.  But a second trial involving prostate cancer patients showed an unexpected and unexplained increase in death rate in patients taking Vitamin D with chemotherapy.

So the answer is “no” – Vitamin D cannot be used to control prostate cancer.

Related Links:

1. Sung V. 1,25-Dihydroxyvitamin D3 decreases human prostate cancer cell adhesion and migration. Mol Cell Endocrinol. 2000;164:133–143.

2. Moffatt KA. Growth inhibitory effects of 1α, 25-dihydroxyvitamin D3 are mediated by increased levels of p21 in the prostatic carcinoma cell line ALVA-31. Cancer Res. 2001;61:7122–7129.

3. Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators. J Clin Oncol. 2007 Feb 20;25(6):669-74.

4. Another Clinical Trial Failure – Ascent-2 https://malecare.org/another-clinical-trial-failure-ascent-2/

5. Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer. J Clin Oncol. 2011 Jun 1;29(16):2191-8.

 

 

 

Can Pomegranate fruit control prostate cancer?

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Some lab studies have indicated that pomegranate fruit is active against prostate cancer. Unfortunately, three separate patient studies have shown only minor activity  in the form of “slowing down of PSA rise”

So “Eat fresh fruit or Drink fresh juice” if you relish it like any other fruit or juice. If there is any effect on prostate cancer, it would be unexpected bonus. But don’t compel yourself to eat or drink it for therapeutic benefit !

Bear in mind that the pomegranate juice or fruit can interfere with some other medications. And I will also state the obvious that “pomegranate is not an approved cancer treatment”.

Links for further reading:

1. Daily Mail. Pomegranate juice ‘can help fight prostate cancer’. http://www.dailymail.co.uk/news/article-393368/Pomegranate-juice-help-fight-prostate-cancer.html

2. Guardian: Consider the pomegranate.  https://www.theguardian.com/lifeandstyle/wordofmouth/2011/feb/01/consider-pomegranate

3.Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clin Cancer Res. Jul 1 2006;12(13):4018-4026.

4. A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer.Prostate Cancer Prostatic Dis. 2013 Mar;16(1):50-5.

5. A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer—the U.K. NCRN Pomi-T study. Prostate Cancer Prostatic Dis. 2014 Jun;17(2):180-6.

6. Is pomegranate juice a potential perpetrator of clinical drug-drug interactions? Review of the in vitro, preclinical and clinical evidence. Eur J Drug Metab Pharmacokinet. 2013 Dec;38(4):223-9. doi: 10.1007/s13318-013-0137-x.

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New test for Prostate cancer

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Research team from Dundee University are developing  a new scan for diagnosis of prostate cancer.  The technique is non-invasive. This novel scan uses an ultrasound process called shear wave elastography (SWE) to detect prostate tumours.

The team’s leader, Professor Ghulam Nabi claims “Our new method is far more accurate and also allows us to identify the difference between cancerous and benign tissue in the prostate without the need for invasive surgery.”

This exciting project was funded by Prostate Cancer UK with support from the Movember Foundation.

The raw data from the paper abstract does call for caution. The test was done in patients who are already known to have prostate cancer. The test was not use to diagnose the cancer. It was a single centre study which usually calls for caution. How well the scan would perform in ” real world” patients who are yet to be diagnosed with prostate cancer remains to be seen.

Early results from about 200 patients are very promising indeed. The test has enormous potential if it is proven to work in a large scale, multi-centre trial.

Links:

  1. The Guardian: https://www.theguardian.com/society/2018/apr/22/prostate-cancer-ultrasound-diagnosis-test.
  2. Daily Mail: http://www.dailymail.co.uk/health/article-5643999/Dundee-scientists-new-non-invasive-ultrasound-detect-prostate-cancer.html.
  3. BBC: http://www.bbc.co.uk/news/uk-scotland-tayside-central-43864875.
  4. Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/29605444

 

Image credit: Anon