Tag: General Health

Surprising Number of Americans Believe Alternative Therapies Can Cure Cancer

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A recent National Cancer Opinion Survey found that a significant Number of Americans Believe Alternative Therapies Can Cure Cancer.

Nearly four in 10 Americans (39%) believe cancer can be cured solely through alternative therapies such as enzyme and oxygen therapy, diet, vitamins, and minerals.

Even many of the respondents with direct cancer experience—people who have or had cancer and family caregivers—believe cancer can be cured solely through alternative medicine.(22% and 38%, respectively).

The American survey also found that younger people are the group most likely to hold these views: 47% of people ages 18 to 37 and 44% of people ages 38 to 53.

It is counterintuitive that the generation with access to vast online information at the swipe of a finger holds such unscientific views. One wonders whether the social media is inadvertently promoting misinformation.

References

1.American Society of Clinical Oncology : Second National Cancer Opinion Survey.

 

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Can Turmeric control cancer ?

Turmeric powder

 

Turmeric is an orange coloured spice widely used in Indian dishes.

Turmeric has been used in Indian traditional medicine (Siddha and Ayurveda).

Turmeric has anti-inflammatory and anti-Cancer properties when tested in laboratories.

Remember – a potential to be beneficial (based on lab studies) is not the same as being proven to work in humans. Lot of substances which are promising in the laboratory eventually turn out to be useless in humans.

If you search PUBMED database- which is an online database of scientific papers- you will find hundreds of papers pertaining to medicinal use of turmeric and its key ingredients such as curcumin. But unfortunately among the many hundreds of published papers, there are very few human trials which have explored turmeric as a anti-cancer treatment.

Inspite of the positive anectodal reports on various internet sites, the available scientific evidence for use of turmeric as an anti-cancer treatment is very spare. ( references below).

Hence it is not worthwhile using turmeric as a cancer treatment.

If you do like Indian dishes, use turmeric as a spice in your normal diet.

But do stay away from the supplements which are sold with health claims.

 

ginger and turmeric powder

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References

The EssentialMedicinal Chemistry of Curcumin.Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA. J Med Chem. 2017 Mar 9;60(5):1620-1637.

Phase I clinical trial of oralcurcumin: biomarkers of systemic activity and compliance.Sharma RA, Euden SA, Platton SL, Cooke DN, Shafayat A, Hewitt HR, Marczylo TH, Morgan B, Hemingway D, Plummer SM, Pirmohamed M, Gescher AJ, Steward WP. Clin Cancer Res. 2004 Oct 15;10(20):6847-54.

A Placebo-Controlled Double-Blinded Randomized Pilot Study of Combination Phytotherapy in Biochemically Recurrent Prostate Cancer.van Die MD, Williams SG, Emery J, Bone KM, Taylor JM, Lusk E, Pirotta MV. Prostate. 2017 May;77(7):765-775.

Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis.Cruz-Correa M, Hylind LM, Marrero JH, Zahurak ML, Murray-Stewart T, Casero RA Jr, Montgomery EA, Iacobuzio-Donahue C, Brosens LA, Offerhaus GJ, Umar A, Rodriguez LM, Giardiello FM. Gastroenterology. 2018 Sep;155(3):668-673.

Effect on prostatic specific antigen by a short time treatment with a Curcuma extract: A real life experience and implications for prostate biopsy.Fabiani A, Morosetti C, Filosa A, Principi E, Lepri L, Maurelli V, Fioretti F, Servi L. Arch Ital Urol Androl. 2018 Jun 30;90(2):107-111.

Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.Sharma RA, McLelland HR, Hill KA, Ireson CR, Euden SA, Manson MM, Pirmohamed M, Marnett LJ, Gescher AJ, Steward WP. Clin Cancer Res. 2001 Jul;7(7):1894.

Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences.Garcea G, Berry DP, Jones DJ, Singh R, Dennison AR, Farmer PB, Sharma RA, Steward WP, Gescher AJ. Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5.

A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer–the U.K. NCRN Pomi-T study.Thomas R, Williams M, Sharma H, Chaudry A, Bellamy P. Prostate Cancer Prostatic Dis. 2014 Jun;17(2):180-6

Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences.Garcea G, Berry DP, Jones DJ, Singh R, Dennison AR, Farmer PB, Sharma RA, Steward WP, Gescher AJ. Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5.

A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer.Kanai M, Yoshimura K, Asada M, Imaizumi A, Suzuki C, Matsumoto S, Nishimura T, Mori Y, Masui T, Kawaguchi Y, Yanagihara K, Yazumi S, Chiba T, Guha S, Aggarwal BB. Cancer Chemother Pharmacol. 2011 Jul;68(1):157.

Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospective phase II trial.Pastorelli D, Fabricio ASC, Giovanis P, D’Ippolito S, Fiduccia P, Soldà C, Buda A, Sperti C, Bardini R, Da Dalt G, Rainato G, Gion M, Ursini F. Pharmacol Res. 2018 Jun;132:72-79.

Monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and curcumin: a randomized, double-blind placebo-controlled cross-over 4g study and an open-label 8g extension study.Golombick T, Diamond TH, Manoharan A, Ramakrishna R. Am J Hematol. 2012 May;87(5):455-60.

 

Image credit: Simon A. Eugster. Turmeric (Curcuma longa):fresh rhizome and powder.

Disclaimer: Please note- This blog is NOT medical advice. This blog is purely for information only. See your own doctor to discuss concerns and options relevant for you.

Does Cranberry juice relieve bladder symptoms due to radiation cystitis?

bowl of red round fruits

Many people do look for natural remedies to help with their symptoms.

Anectodally, many patients undergoing radiotherapy have reported that Cranberry Juice has eased their radiation cystitis symptoms.

What is the scientific evidence behind it ?

Should all patients having cystitis symptoms during radiotherapy take cranberry juice?

There is certainly scientific basis to expect benefit from Cranberry Juice.(1).

A lab study and a volunteer study (with volunteers from Japan, Hungary, Spain and France) has shown that certain chemicals in Cranberry can make bacteria ‘less sticky‘ to urinary tract walls and hence potentially reduces virulence of the bacteria.(1). But subsequent large studies have NOT confirmed any large benefit from Cranberry in terms of treating or preventing urinary tract infections. (2)(3).

But Radiation Cystitis is not due to bacterial infections although infections can co-exist sometimes. Hence the use of Cranberry has been studied separately in patients undergoing radiation therapy.

A New Zealand study involved 41 men undergoing radiotherapy for prostate cancer. Taking Cranberry (one capsule a day at breakfast) was found to reduce symptoms of pain and burning. (4).

On the other hand, in a study from Canada involving 112 patients , consumption of Cranberry juice compared with apple juice had no effect on radiation cystitis symptoms. (5).

Another study from United Kingdom was inconclusive because of poor patient recruitment and poor compliance. (6).

So the scientific evidence is inconclusive at present.(7).

Practically, if someone is keen to try it – the best course of action – ( for someone not intolerant of cranberry juice) – is to try it and see whether it offers any symptomatic benefit .

Disclaimer: Please note- This is NOT medical advice. This blog is purely for information only. See your own doctor to discuss options.

There are prescription medications available to help with radiation cystitis symptoms.

References:

1.Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study. BMC Infect Dis. 2010 Apr 14;10:94.

2. BBC News. Does Cranberry juice stop cystitis. By Claudia Hammond. (Accessed 1st Jan 2019).

3. BBC News. Ditch cranberry juice for urine infection . (Accessed 1st Jan 2019).

4.Standardized cranberry capsules for radiation cystitis in prostate cancer patients in New Zealand: a randomized double blinded, placebo controlled pilot study. Support Care Cancer (2015) 23: 95.

5. A Randomised Trial of Cranberry Versus Apple Juice in the Management of Urinary Symptoms During External Beam Radiation Therapy for Prostate Cancer. G.Campbell et al. Clin Oncol (R Coll Radiol). 2003 Sep;15(6):322-8.

6. A Randomised Double-blind Placebo-controlled Trial to Determine the Effect of Cranberry Juice on Decreasing the Incidence of Urinary Symptoms and Urinary Tract Infections in Patients Undergoing Radiotherapy for Cancer of the Bladder or Cervix. Cowan CC, et al. Clin Oncol (R Coll Radiol). 2012.

7.Chemical- and radiation-induced haemorrhagic cystitis: current treatments and challenges. BJU Int. 2013 Nov;112(7):885-97.

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Low carbohydrate diet

The advocates of low-carb diet received a scientific boost recently.

An American trial, published recently in the British Medical Journal, compared the effects of low-carb-high-fat diet with high-carb-low-fat while keeping total calories and protein intake constant.

This elegantly done trial shows that carbohydrates are bad for weight loss. A diet with a combination of low-carb-high-fat content was the winner in this trial and it promoted energy loss and helped maintain weight loss.

Reference:

Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial.

Can alcohol cause cancer?

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Can alcohol cause cancer?

Yes,  worldwide, 1 in 20 cancers are attributed to alcohol .

How much drinking causes cancer?

“Even modest use of alcohol may increase cancer risk, but the greatest risks are observed with heavy, long-term use”

“The more that a person drinks, and the longer the period of time, the greater their risk of development of cancer, especially head and neck cancers”

Are light drinkers at risk ?

Risk of cancer is present at  even at low levels of consumption.  Hence, the World Cancer Research Fund/AICR makes the following recommendation: “If alcoholic drinks are consumed, limit consumption to two drinks a day for men and one drink a day for women.” They also recommend that, “for cancer prevention, it’s best not to drink alcohol.”

Is wine less risky than spirits?

No,  the risk is present “regardless of the specific type of alcoholic beverage (ie, beer, wine, or spirits/liquor)”

Which cancers can arise due to alcohol?

Alcohol is causally associated with Mouth, Throat, Gullet, Liver, Breast and Bowel cancers.

Links:

  1. Alcohol and Cancer: A Statement of the American Society of Clinical Oncology. http://ascopubs.org/doi/full/10.1200/JCO.2017.76.1155
  2. Alcohol is a direct cause of seven ​​forms of cancer, finds study . https://www.theguardian.com/society/2016/jul/22/alcohol-direct-cause-seven-forms-of-cancer-study

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